Oh, you mean stuff like one table one entry holding settings. From practical point of view I would say, forget it, other things will kill the server far before this had a chance to affect it. With one static entry the odds are it will be always cached and served from memory (not sure how exactly cache works, but that's the most logical option) also any differences between any storage engines/DB types would be meaningless. From theorethical point of view I would say, go for pregenerated setting file.