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I would just make sure users are aware that the ads are there to fund the website and without the ads there would be no website. In addition to this allow users to report any bad ads and take their comments seriously - if you have to, remove that specific ad from the pool. This sort of thing should be easy when you're working with a community, such as at a browser based game.
And ad blockers tend to work only for deployed advertising systems. If you create your own ad system, the odds are small that it will block your ads. Unless, of course, you're using pop up advertisements. In which case, any pop-up blocker worth its salt can detect when javascript is attempting to open a new window (or tab, depending on your browser).
Ad Blocker Plus does indeed blocks these, I'm not sure if we made there list of advertisers (I wouldnt think so) or they just immediately block iframe content with a source outside the domain.
Unlike TV ads, radio spots etc etc there is a good amount of money that must be put out to enter that market, with the internet all it takes is a couple minutes of time and zero money.